Coalesce Biosciences | Precision Toxicology

Precision toxicology for
real-world threats.

Advancing preclinical testing for highly hazardous biological and chemical threat agents through specialized research and unmatched expertise.

Rigorous models for high-consequence agents.

Coalesce Biosciences is a specialized Contract Research Organization (CRO) advancing preclinical testing for highly hazardous biological and chemical threat agents. We operate at the leading edge of biodefense and industrial safety. Coalesce is uniquely positioned with the regulatory clearance and specialized infrastructure required to handle Schedule I and II chemical agents and high-potency biological toxins. Our facilities are designed for the secure management of hazardous substances that many other labs simply cannot accommodate.

Hazardous Agent Research

Schedule I and II select chemical agents and biological toxins.

Targeted Organ Toxicology

Dermal, pulmonary, neural, and ocular system assessments.

Animal & Human Organoid Model Development

In vitro screening tools and in vivo model validation.

Countermeasure Development

MCM efficacy, safety profiles, and natural history studies.

Analytical Dynamics

Pharmacokinetic modeling, dose-response, and mechanism of injury.

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Science at the frontline
of biological and chemical defense.

Coalesce Biosciences operates at the intersection of academic rigor and translational impact, bridging the gap between basic toxicological research and the critical need for medical countermeasures.

Coalesce Biosciences is strategically headquartered within Winston-Salem's Innovation Quarter, one of the fastest-growing urban innovation districts in the United States. This location places us at the heart of a vibrant biotech ecosystem, fostering direct collaboration with academic leaders, clinical investigators, and industry innovators.

Innovation Quarter | Winston-Salem, NC

Institutional Synergy

Coalesce Biosciences is strategically integrated with the Wake Forest School of Medicine and the Wake Forest Institute for Regenerative Medicine (WFIRM). This deep relationship provides our team and partners with unparalleled access to the field of regenerative medicine and world-class facilities.

By working alongside leading scientists and leveraging innovative technologies, we translate basic research into high-fidelity models and life-saving countermeasures. This synergy ensures that our preclinical studies benefit from the most advanced scientific insights and cutting-edge laboratory infrastructure available today.

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Laboratory Infrastructure

Chemical Countermeasures & Synthesis Laboratory

Facility Specifications

Select Agent Space

10,200 sq ft of neat agent research space

Academic Research space

3,000 sq ft with access to core resources

Specialized Vivarium

Capable of housing both rodents and USDA species.

Translational Models

Expertise in mice, rats, guinea pigs, rabbits, swine, and NHP.

Synthesis & Storage

In-house chemical synthesis and storage facilities.

Technical Capabilities

Next-Gen Organoids

High-fidelity, human-derived organoids providing mechanistic insights into tissue-specific injury.

Exposure Protocols

Precision-engineered delivery systems mimicking real-world inhalation and dermal scenarios.

Vesicant Modeling

Development and validation of proprietary chemical vesicant exposure models for high-fidelity in vivo studies.

Collaboration Frameworks

Academic Institutions

Collaborative research programs with leading universities, bridging basic science and medical defense countermeasures.

Government Contracts

Direct performance of R&D for federal health security, defense, and preparedness agencies.

Industry Partnerships

Strategic alliances with biotech and pharmaceutical leaders to accelerate MCM product development.

Fee for Service

Direct CRO services for standardized or customized safety and efficacy studies for therapeutic candidates.

Wake Forest University Vesicant Exposure Resource and Coordination Core (Vesicant ExRC)

The NIH Chemical Countermeasures Research Program (CCRP) is a component of the broader civilian biodefense research effort. Its mission is to integrate cutting-edge research with the latest technological advances in science and medicine to enhance national medical and public health preparedness for, response to, and recovery from disasters and public health chemical emergencies.

Official NIH CCRP Program

The Wake Forest University Vesicant Exposure Resource and Coordination Core (Vesicant ExRC) provides a state-of-the-art facility dedicated to accelerating the development of medical countermeasures for hazardous chemical injuries. Led by a multidisciplinary team of experts, the program offers investigators a comprehensive suite of advanced in vivo, ex vivo, and in vitro experimental models focused on ocular, dermal, and pulmonary tissues. By standardizing innovative analytical methods and fostering collaboration, the Vesicant ExRC streamlines the study of toxic mechanisms to enhance national chemical research and preparedness. See the 2025 Program Portfolio for current CCRP-supported projects.

Embedded within a leading academic medical center, the Vesicant ExRC delivers rigorous toxicology and translational research for government and academic partners. We provide end-to-end support for studies involving Schedule I & II chemical agents, combining academic scientific depth with mission-focused execution to support the NIH civilian biodefense research effort.

We specifically support university research teams utilizing federal grant mechanisms to explore toxicological mechanisms and develop life-saving medical countermeasures. Through our unique partnership with the Wake Forest Institute for Regenerative Medicine, we provide access to high-fidelity organoid and animal models.

2025 Program Portfolio

Supporting the NIH Research Mission

Investigator Support

Providing the high-containment infrastructure and rigorous methodological standards required for specialized NIH research project grants.

Rapid Innovation

Facilitating exploratory science through rapid model validation and specialized toxicological screening platforms for developmental projects.

Select Agent Security

Handling the regulatory and safety requirements for neat agents, allowing academic investigators to focus purely on the scientific innovation of their proposals.

Collaborative Funding & Mission Support

The Vesicant ExRC actively partners with academic investigators from major research universities to strengthen federal biodefense applications, specifically:

NIH U2C Grants

NIH R01 Research Grants

NIH R21 Exploratory Grants

CounterACT U01 Projects

Grant Success Through Partnership

"By partnering with the Vesicant ExRC as your specialized research core, your NIH grant application gains immediate access to the regulatory clearance, specialized modeling capacity, and high-containment facility needed to win federal awards."

Preclinical Research

Coalesce Biosciences provides a comprehensive preclinical research platform designed to bridge the gap between basic toxicological discovery and mission-critical countermeasures. Our business model offers partners deep expertise in multiple organ system toxicology and precision-engineered chemical and biological exposure delivery systems. We specialize in conducting rigorous medical countermeasure efficacy and safety studies, supported by sophisticated analytical dynamics to define the mechanisms of injury and the trajectory of recovery.

Precision toxicology for
real-world threats.

Rigorous models for high-consequence agents.

Hazardous Agent Research

Targeted Organ Toxicology

Animal & Human Organoid Model Development

Countermeasure Development

Analytical Dynamics

Start an Inquiry

Science at the frontline
of biological and chemical defense.

Institutional Synergy

Laboratory Infrastructure

Facility Specifications

Technical Capabilities

Next-Gen Organoids

Exposure Protocols

Vesicant Modeling

Collaboration Frameworks

Academic Institutions

Government Contracts

Industry Partnerships

Fee for Service

Wake Forest University Vesicant Exposure Resource and Coordination Core (Vesicant ExRC)

Supporting the NIH Research Mission

Investigator Support

Rapid Innovation

Select Agent Security

Collaborative Funding & Mission Support

Grant Success Through Partnership

Preclinical Research

Unmatched expertise for
toxic agent research.

Leadership & Science

Strategic Advisors

Precision toxicology for real-world threats.

Rigorous models for high-consequence agents.

Hazardous Agent Research

Targeted Organ Toxicology

Animal & Human Organoid Model Development

Countermeasure Development

Analytical Dynamics

Start an Inquiry

Science at the frontline of biological and chemical defense.

Institutional Synergy

Laboratory Infrastructure

Facility Specifications

Technical Capabilities

Next-Gen Organoids

Exposure Protocols

Vesicant Modeling

Collaboration Frameworks

Academic Institutions

Government Contracts

Industry Partnerships

Fee for Service

Wake Forest University Vesicant Exposure Resource and Coordination Core (Vesicant ExRC)

Supporting the NIH Research Mission

Investigator Support

Rapid Innovation

Select Agent Security

Collaborative Funding & Mission Support

Grant Success Through Partnership

Preclinical Research

Unmatched expertise for toxic agent research.

Leadership & Science

Strategic Advisors

Precision toxicology for
real-world threats.

Science at the frontline
of biological and chemical defense.

Unmatched expertise for
toxic agent research.